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Bottom line, per case:
1. always check for extension records
2. always use the negative cache (after fast positive tests), and customize the code in the JIT (GraphKit::gen_subtype_check)
3. customize in the JIT; negative cache buys nothing
4. customize in the JIT if possible; negative cache buys nothing
5. let the JIT do its thing for intrinsics; use the negative cache for Class.isInstance and Class.isAssignableFrom

References

• http://blogs.sunoracle.com/jrose/entry/interface_injection_in_the_vm
• http://journal.thobe.org/2008/07/my-jvm-whishlist-pt-1-interface.html